In addition to softening wrinkles, Botox is used to treat a variety of medical conditions including severe spasms in the neck, uncontrolled eyelid spasms, migraine headaches, excess sweating, and urinary incontinence. Several studies indicate that Botox treatments for frown lines between the brow can significantly elevate the mood of individuals suffering from depression. A study released last year, demonstrated that 52 percent of participants who suffered from moderate to severe depression found relief from Botox injections, compared to 15 percent who received a placebo. Plus, nearly a third of the Botox patients went into remission.
Two other studies revealed the same and in one, not only did Botox help with depression, but the effects continued even after the cosmetic changes wore off. The exact mechanism of action isn’t clear but might involve a feedback theory which states that facial expressions influence mood. It’s possible that by relaxing the frown muscles a signal is sent to the brain, improving a person’s mood. Botox for depression is currently used off-label and is in clinical trials for FDA approval.